Ran into a problem today where I was getting HTTP Error 404.17 after setting up Windows 7 64-bit with IIS7.
"HTTP Error 404.17 - Not Found - The requested content appears to be script and will not be served by the static file handler."
The ISAPI DLL is a 32-bit DLL, so you'll have to either change your default Application Pool to enable 32-bit, or create a separate 32-bit AppPool for your application.
To Enable 32-bit Applications right click on the Application Pool and select "Advanced Settings" then "Enable 32-bit Applications."
Thanks to Scott Hanselman for sharing his solution.
http://www.hanselman.com/blog/HTTPError40417PHPOnIIS7Under64bitVista.aspx
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